OK stop what you're doing. Right now. Cancel all prior arrangements. Go out to see Mulholland Drive. And then when you get back be sure to let me know what the fuck was going on there. But if like me you are left scratching your head at the end, don't worry, as you'll have had fun trying to figure it all out. Whatever its meaning, the film features all that you would want from a classic movie - car crashes; gorgeous women; sinister midgets; hilariously inept hitmen; a menacing cowboy; an amnesiac with a handbag full of cash; a mystery box; in-jokes; wild plot turns and lashings of lesbian sex. Once you have seen the film, (and no sneak peeking before you do, it'll spoil your fun) you might want to check out Salon's explanation of the plot. Seems quite feasible, although I'm sure the blue and red lights seen at various stages of the film were meant to signify something as well? If you want to delve any deeper however, you could always read the original screenplay.